PreventionGenetics was founded in 2004 by current CEO Dr. James Weber, who was a major contributor to the Human Genome Project. They are located in Wisconsin, USA, and strive to provide clinical genetic testing to help people improve their lives.
The company states that many of their geneticists participate in ClinGen expert gene curation groups, which is dedicated to developing a central source to describe the clinical relevance of genes and variants for precision medicine and research.
They have partnered with pharmaceutical companies and non-profit organizations to offer no-cost tests to patients who qualify for the programs or studies.
PreventionGenetics offers clinical DNA testing through medical professionals to aid with the diagnosis of genetic conditions. To get started, patients must consult with their healthcare provider, who will then fill out a form with the patient’s information, the test selected, and any additional clinical information. The company requires a copy of the clinical records to be attached to this form.
The PGnome Diagnostic test offers Whole Genome Sequencing (WGS) to analyze the entire genome. This test is designed for diagnosis, the assessment of disease risks, pharmacogenetics, and more. The results are ready in 28 days.
PreventionGenetics provides four options for this test, depending on the number of family members tested, as listed below:
The PGxome Diagnostic Exome Test assesses almost all genes from the human genome, including coding regions. This test is recommended for healthcare professionals who are looking for a diagnosis and did not have success with previous diagnostic methods. The results are delivered in 30 calendar days.
Similar to the PGnome Diagnostic, the company also offers four options for this test, depending on the number of family members tested. PreventionGenetics offers an express option for this test in which the results are delivered in 14 days.
The PGxome Health Screen Exome Test is intended for patients who wish to find out their carrier status for recessive diseases and learn their susceptibility to adult-onset disorders.
The company offers a Prenatal Exome Test for ongoing pregnancies that present ultrasound findings consistent with serious genetic conditions. Additionally, they offer Custom Panels for WES that are customizable to fit the patient’s specific needs.
The Targeted Variants tests offer single, double, or triple variant sequencing for any gene on the PreventionGenetics test menu.
Furthermore, the company offers the DNA Banking service that provides patients with a secure place to store their DNA for future use. DNA Banking is a direct-to-consumer service. After extraction, DNA is stored in secure freezers at multiple locations.
PreventionGenetics’ reports are divided into up to six sections. The primary findings section covers the results related to the patient’s clinical presentation, as seen in the sample report below. The report provides the genes known to be associated with phenotype and those possibly associated with the phenotype.
Patients can opt-in to receive additional information about 59 medically actionable variants from the American College of Medical Genetics recommended list of genes. Users can also choose to learn about variants in genes that may result in a Mendelian Disorder, which can occur due to alterations in one gene or as a result of abnormalities in the genome.
The company offers information about carrier status and rare variants for which there is little or no evidence to suggest a connection with human disease.
The report presents additional information about the test performed and its limitations. The company also gives a few recommendations about further tests and explains if a genetic counseling session is necessary, as seen below.
The company thoroughly explains their findings and supports their claims with scientific evidence.
Since the reports are meant for healthcare professionals, the language used is very technical and not easily understood by those outside the medical field. As stated before, PreventionGenetics offers a few clinical recommendations to the healthcare provider, but they do not make any suggestions to help patients manage their genetic conditions.
Prices vary according to the test selected and the number of family members tested. For the PGnome Diagnostic, the prices are listed below.
The PGxome Diagnostic Exome Test prices are as follows:
The Prenatal Exome Test prices range from $2,860 to $3,590. The Custom Panel prices are determined by the number of genes selected and it can cost $390 to $1,790.
The Targeted Variants test can cost up to $990. The DNA Banking service is priced at $169 per person.
PreventionGenetics is a contracted provider for Medicare and Wisconsin Medicaid, and several other health plans.
PreventionGenetics does not provide any health recommendations directly to the patient. The company may offer healthcare professionals additional testing suggestions and recommends genetic counseling when it is needed.
PreventionGenetics states they are required by the Health Insurance Portability and Accountability Act (HIPAA) to keep protected health information (PHI) confidential. They may disclose PHI if it is necessary for the patient’s treatment, and to receive payment for the services provided. For example, the company says they may share PHI with insurance companies or health plans.
They may disclose PHI for public health-related activities and non-profit research purposes. Patients have the right to inspect and copy the PHI maintained by the company.
SelfDecode
Prevention Genetics
GeneDx
Ambry Genetics
Personalized & holistic health recommendations
Number of genetic variants analyzed
Up to 83 million genetic variants
Unknown / Not Disclosed
DNA testing; health and wellness reports; diet, lifestyle, and supplement recommendations
WGS, WES, disease reports, DNA bank
WGS, WES, disease reports
DNA testing for health conditions, patent and provider options
Raw data access
Depends on insurance coverage
SelfDecode: Health-focused DNA analysis that delivers personalized diet, lifestyle, and supplement recommendations through detailed health reports.
PreventionGenetics provides tools to help healthcare professionals diagnose genetic conditions. Patients cannot order tests from the company on their own, and they need to consult with a medical provider to get access to their services. The company does not offer recommendations to their customers, and the reports use technical language to communicate the findings.
While an accurate diagnosis is crucial to help patients treat diseases, other services like SelfDecode can offer personalized health recommendations that can be easily implemented without having to contact a doctor. SelfDecode also has professional plans for medical providers to help with the individualization of care for their patients.
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